| Xanthine oxidase | |||||
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Xanthine oxidase is an enzyme protein which oxidises xanthine to uric acid and of many aldehydes to acids.
Xanthine oxidase is a complicated protein enzyme which contains flavins, molybdenum, iron and sulfide cofactors.
Important xanthine oxidase facts
- Xanthine oxidase (XO) is involved in free radical production, especially in people with diabetes type 1
- Xanthine oxidase is normally found only in the liver
- Xanthine oxidase is a unimolecular, multicomponent electron transport systm
- Xanthine oxidase is a a superoxide-generating enzyme
- Bovine (cow) milk contains xanthine oxidase
Why xanthine oxidase is important
Xanthine oxidase is implicated in free radical damage due to its activty in the body and should be prevented.
Last reviewed: 21 August 2007 || Last updated: 14 March 2010
Related Articles
references
- Amudha G, Josephine A, Sudhahar V, Varalakshmi P. Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity. Int Immunopharmacol. 2007 Nov;7(11):1442-9. Epub 2007 Jul 17
- Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N. Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol. 2007 Oct;43(4):437-444. Epub 2007 Jul 31
- Protti A, Singer M. Oxidative stress and critical illness. Minerva Anestesiol. 2007 May;73(5):255-7, accessed 30 Sep 07
- Taibi G, Nicotra CM. Xanthine oxidase catalyzes the oxidation of retinol. J Enzyme Inhib Med Chem. 2007 Aug;22(4):471-6
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Disclaimer: This guide is not intended to be used for diagnostic or prescriptive purposes. For any treatment or diagnosis of illness, please see your doctor.
